Frusemide

30 11 2012

What is it ?

Lasix. oral + IV forms.
loop diuretic. selectively inhibit NaCl reabsorption in the Thick Ascending Loop (TAL)

PHARMACODYNAMICS

 

Thick ascending loop of Loop of Henle

 

inhibit NKCC2, the luminal Na+/K+/2CL-transporter in the TAL of Henle’s loop.
hence :
a. REDUCING the reabsorption of NaCl
b. also diminish the lumen-positive potential that comes from K+ recycling >>>> increase in M+ and Ca2+ excretion

induce expression of cyclooxygenases (COX-2) >>>more synthesis of PG from AA

increases renal blood flow via PG actions on kidney vasculature

PHARMACOKINETICS

rapid absorption.
eliminated via glomerular filtration + tubular secretion.
duration of effect ~2-3 hours.

 

CLINICAL INDICATIONS

Acute pulmonary oedema

Acute hypercalcemia.

Hyperkalaemia

Acute Renal Failure

Anion OVerdose

TOXICITY

Hypoklaemic Metabolic Alkalosis

Ototoxicity

Hyperuricemia

Hypomagnesemia

Allergic reactions

 

 

MCQ questions :

3. which is NOT true of diuretics?

a. Loop diuretics can be used to treat hypercalcaemia
b. Frusemide is used in the prophylaxis of acute mountain sickness
c. Cirrhotic oedema responds to spironolactone
d. They may enhance the efficiency of ACE inhibitors
e. Hydrochlorothiazide is useful in diabetes insipidus
ANSWER : B

Viva questions : http://lifeinthefastlane.com/exams/facem-primary/pharmacology-viva/pharm20100212/


Actions

Information

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s




%d bloggers like this: